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adhesin |
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adhesin [adhē′sin] a bacterial product that enables bacteria to adhere to and colonize a host. Adherence is often an essential step in pathogenesis. Adhesins are attractive candidates for vaccines and/or components of accellular vaccines such as those for pertussis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Interest in a potential attenuated live vaccine has
been stimulated by the finding that targeted disruption of the
Blastomyces dermatitidis gene, which encodes the surface adhesin BAD-l,
renders the mutant avirulent. These novel adhesins are being
used by Inhibitex to develop a pipeline of immunotherapeutics targeting
the treatment and prevention of hospital acquired infections caused by
antibiotic-resistant staphylococci, including S. This bacterium expresses adhesins such
as filamentous hemagglutinin, pertactin, fimbriae (FIM), and toxins such
as pertussis toxin, and adenylate cyclase-hemolysin (4). |
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