In addition, [beta]-catenin is a critical component of the cadherin-mediated cell adherens junction
adhaerens are interconnected by apical junctions that resemble the adherens junctions
of other metazoans (Ruthmann et al.
The loss of E-cadherin leads to the release of [beta]-catenin from adherens junctions
to the cytoplasm and inactivates GSK-3[beta].
Disruption of binding between [beta]-catenin and VE-cadherin interferes with the association of adherens junctions
with the actin cytoskeleton, therefore resulting in decreased cell adhesion strength and subsequent barrier disruption .
Unlike adherens junctions
, hemidesmosomes affix the basal plasma membrane to the tissue's basal membrane (cell-extracellular matrix junction) via integrins a6P4 and laminin 5 filaments.
Molecular and functional analysis of cadherin-based adherens junctions
Among the topics are cadherins, adherens junctions
and desmosomes, integrins and focal contacts, receptor tyrosine phosphatases, Notch and Slit-Robo signaling, adhesive binding to collagen and fibrillin, and complex adhesive mechanisms involved in leukocyte migration and malaria.
Adjudinmediated junction restructuring in the seminiferous epithelium leads to displacement of soruble guanylate cyclase from adherens junctions
," Journal of Cellular Physiology 208(1): 175-187.
Much of this is performed via three mechanisms existing between the intestinal microvilli: tight junctions, adherens junctions
Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions
The epithelial monolayer is sealed by an array of intra- and intercellular protein-protein interactions, which form intercellular junctions consisting of the apically localized tight junctions (TJs) along with the adjacent adherens junctions
(AJ) and desmosomes .
(AJs) are defined by the presence of cadherins (Takeichi, 1991), and are the major junctional type required for cell-cell adhesion across the Metazoa (Oda et al.