adherens junction

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adherens junction

a component of the junctional complex just beneath and supporting the zonula occludens. The extracellular space at the adherens junction is spanned by the extracellular aspects of cadherin molecules, the intracellular aspects of which are supported by actin filaments.

Adherens Junction

A protein complex located at the junction between epithelial cells, which are subjected to stretching and pulling, yet require tight contact between them so they can function as a single unit. Adherens junctions are linked to the cell’s actin cytoskeleton, and take two forms: as bands encircling the cell—zonula adherens—or as “spot welds” to the extracellular matrix—adhesion plaques. Adherens junctions are composed of 4 principle proteins: cadherins and alpha-catenin, plakoglobulin (aka beta or gamma catenin) and p120 (aka delta catenin).

adherens junction

A point of junction between cells at which ACTIN filaments from inside the cells pass across the adjacent cell membranes. A broad, belt-like adherens junction is called an adhesion belt.
References in periodicals archive ?
Molecular and functional analysis of cadherin-based adherens junctions.
Since adherens junctions are assembled from a large number of proteins, these molecules have to be coordinately activated and spatially regulated.
Blood-testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors," Proceedings of the National Academy of Sciences 102(33): 11722-11727.
Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/[beta]-catenin (CATNB) signaling pathway: An in vitro and in vivo study," Biology of Reproduction 73(3): 458-471.
Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: A review of recent data," Developmental Biology 286(1): 1-15.
NACHYLINE[R]: NACHYLINE[R] stimulates both the formation of adherens junctions and keratinocyte differentiation, reinforcing thus the cohesion and the stratification of the epidermis.
Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis," Journal of Andrology 25(2): 200-215.
Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: Is this a potential target for male contraceptive development?
Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?
Fer kinase/Fer T and adherens junction dynamics in the testis: An in vitro and in vivo study," Biology of Reproduction 69(2): 656-672.