adherens junction

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adherens junction

a component of the junctional complex just beneath and supporting the zonula occludens. The extracellular space at the adherens junction is spanned by the extracellular aspects of cadherin molecules, the intracellular aspects of which are supported by actin filaments.

Adherens Junction

A protein complex located at the junction between epithelial cells, which are subjected to stretching and pulling, yet require tight contact between them so they can function as a single unit. Adherens junctions are linked to the cell’s actin cytoskeleton, and take two forms: as bands encircling the cell—zonula adherens—or as “spot welds” to the extracellular matrix—adhesion plaques. Adherens junctions are composed of 4 principle proteins: cadherins and alpha-catenin, plakoglobulin (aka beta or gamma catenin) and p120 (aka delta catenin).

adherens junction

A point of junction between cells at which ACTIN filaments from inside the cells pass across the adjacent cell membranes. A broad, belt-like adherens junction is called an adhesion belt.
References in periodicals archive ?
In addition, [beta]-catenin is a critical component of the cadherin-mediated cell adherens junction.
adhaerens are interconnected by apical junctions that resemble the adherens junctions of other metazoans (Ruthmann et al.
The loss of E-cadherin leads to the release of [beta]-catenin from adherens junctions to the cytoplasm and inactivates GSK-3[beta].
Disruption of binding between [beta]-catenin and VE-cadherin interferes with the association of adherens junctions with the actin cytoskeleton, therefore resulting in decreased cell adhesion strength and subsequent barrier disruption [67].
Unlike adherens junctions, hemidesmosomes affix the basal plasma membrane to the tissue's basal membrane (cell-extracellular matrix junction) via integrins a6P4 and laminin 5 filaments.
Molecular and functional analysis of cadherin-based adherens junctions.
Among the topics are cadherins, adherens junctions and desmosomes, integrins and focal contacts, receptor tyrosine phosphatases, Notch and Slit-Robo signaling, adhesive binding to collagen and fibrillin, and complex adhesive mechanisms involved in leukocyte migration and malaria.
Adjudinmediated junction restructuring in the seminiferous epithelium leads to displacement of soruble guanylate cyclase from adherens junctions," Journal of Cellular Physiology 208(1): 175-187.
Much of this is performed via three mechanisms existing between the intestinal microvilli: tight junctions, adherens junctions and desmosomes.
Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.
The epithelial monolayer is sealed by an array of intra- and intercellular protein-protein interactions, which form intercellular junctions consisting of the apically localized tight junctions (TJs) along with the adjacent adherens junctions (AJ) and desmosomes [27].
Adherens junctions (AJs) are defined by the presence of cadherins (Takeichi, 1991), and are the major junctional type required for cell-cell adhesion across the Metazoa (Oda et al.