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Advanced Elements of Pacing Trial. A trial comparing dual chamber pacemakers without rate response (DDD) and dual chamber pacemakers with rate response (DDDR).
An implantable cardioverter-defibrillator (ICD) that aggressively modulates heart rate (e.g., with DDDR pacing) does not improve exercise capacity or quality of life compared with non-aggressive pacing (e.g., DDD). Atrial fibrillation is more common with mode switching (MS) on; hospitalisation for CHF is more common with MS off.
Antibody-directed enzyme prodrug therapy. A treatment protocol intended to decrease therapeutic cytotoxicity of certain drugs by administering an inactive prodrug and a monoclonal antibody that carries the prodrug’s activating enzyme to the target site.
Adolescent Depression Prevention and Treatment. A study funded by the National Institute of Mental Health, examining the cost-effectiveness of a “service” model for treating children of depressed adults enrolled in health maintenance organisations (HMOs).