Addison disease


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to Addison disease: Cushing syndrome

chron·ic a·dre·no·cor·ti·cal in·suf·fi·cien·cy

adrenocortical insufficiency usually as the result of idiopathic atrophy or destruction of both adrenal glands by tuberculosis, an autoimmune process, or other diseases; characterized by fatigue, decreased blood pressure, weight loss, increased melanin pigmentation of the skin and mucous membranes, anorexia, and nausea or vomiting; without appropriate replacement therapy, it can progress to acute adrenocortical insufficiency.

Addison’s disease

An endocrinopathy characterised by decreased production of aldosterone and cortisol.
 
Aetiology
Autoimmunity (90%), trauma, haemorrhage, tuberculosis, pituitary gland destruction, amyloid, infection (e.g., meningococcal septicaemia), surgical excision.

Clinical findings
Weakness, hypotension, easy fatigability, weight loss, nausea, vomiting, abdominal pain, muscle and joint pain, amenorrhea, bronzing of skin and hyperpigmentation (especially at skin folds), scars, palmar creases, loss of body hair.

Lab
Anaemia, neutropenia, eosinophilia, lymphocytosis, hypoglycaemia, reduced Na+, decreased cortisol, increased Ca2+, increased K+, increased BUN, dehydration.
 
Management
Hydrocortisone, fludrocortisone.
 
Warning
Patients should wear medical alert bracelet.

chron·ic a·dre·no·cor·ti·cal in·suf·fi·cien·cy

(kron'ik ă-drē'nō-kōr'ti-kăl in'sŭ-fish'ĕn-sē)
Adrenocortical insufficiency usually as the result of idiopathic atrophy or destruction of both suprarenal glands by tuberculosis, an autoimmune process, or other diseases.
Synonym(s): Addison disease.

Addison,

Thomas, English physician, 1793-1860.
Addison anemia - a chronic, progressive anemia of older adults due to failure of absorption of vitamin B12. Synonym(s): Addison-Biermer disease; addisonian anemia; Biermer anemia; Biermer disease; pernicious anemia
Addison-Biermer disease - Synonym(s): Addison anemia
Addison disease - Synonym(s): chronic adrenocortical insufficiency
addisonian anemia - Synonym(s): Addison anemia
addisonian crisis - Synonym(s): acute adrenocortical insufficiency
Addison-Schilder disease - Synonym(s): Schilder disease