adapter protein

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adapter protein

An intracellular molecule that undergoes structural and functional changes in response to binding of cell membrane receptors by ligands. Adapter proteins participate in the immune response by acting as a bridge for enzymes in the signaling pathway needed to activate lymphocytes and initiate a response to an antigen.
See also: protein
References in periodicals archive ?
Maslinic acid was shown to affect the expression of proteins involved in nucleotide metabolism, microtubule filament assembly, cytoskeleton organization, and adaptor proteins in the signal transduction pathway.
Cysteine-based regulation of the CUL3 adaptor protein Keap1.
A position is available to study the function of the ShcC adaptor protein in the regulation of signal transduction cascades controlled by tyrosine kinases.
The adaptor protein ankyrinG is essential for the assembly of this diffusion barrier and crosslinks ion channels and adhesion molecules to the cytoskeleton.
To address this challenge, the Lunenfeld collaborated with AB SCIEX scientists to utilize the AB SCIEX QTRAP 5500 System coupled to an Eksigent NanoLC Ultra + cHiPLC nanoflex liquid chromatography system to design a new approach, which the Canadian researchers used to investigate changes in protein interactions with the adaptor protein GRB2, an important hub in growth factor signaling.
Growth factor receptor bound protein-2 (Grb-2) is an adaptor protein that has shown to be involved with several types of cancer.
While the data presented at FOCIS 2009 are on TLRs 3, 7, and 9, we also have identified antisense compounds for TLRs 2, 4, 5, 6, and 8 and the adaptor protein MyD88.
As described by Glimcher and her colleagues, this adaptor protein, or "master switch," regulates the growth of cells called osteoblasts that are responsible for bone formation.
In a second line of investigation, other, as yet unknown, proteins that might be involved in this process, like priming factors, and scaffold and adaptor proteins will be explored.
This research, attempting to study roles of adaptor proteins, TLR3 and MyD88, is important in providing a deeper understanding of TLR3's role in corneal inflammation, allowing for better designs in more effective anti-viral therapies.
Linker or adaptor proteins act as scaffolds that organize the signaling proteins that cells need to proliferate and mature.

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