Maslinic acid was shown to affect the expression of proteins involved in nucleotide metabolism, microtubule filament assembly, cytoskeleton organization, and adaptor proteins
in the signal transduction pathway.
Cysteine-based regulation of the CUL3 adaptor protein
Src-like adaptor protein
regulates B cell development and function.
A position is available to study the function of the ShcC adaptor protein
in the regulation of signal transduction cascades controlled by tyrosine kinases.
The adaptor protein
ankyrinG is essential for the assembly of this diffusion barrier and crosslinks ion channels and adhesion molecules to the cytoskeleton.
To address this challenge, the Lunenfeld collaborated with AB SCIEX scientists to utilize the AB SCIEX QTRAP 5500 System coupled to an Eksigent NanoLC Ultra + cHiPLC nanoflex liquid chromatography system to design a new approach, which the Canadian researchers used to investigate changes in protein interactions with the adaptor protein
GRB2, an important hub in growth factor signaling.
Growth factor receptor bound protein-2 (Grb-2) is an adaptor protein
that has shown to be involved with several types of cancer.
While the data presented at FOCIS 2009 are on TLRs 3, 7, and 9, we also have identified antisense compounds for TLRs 2, 4, 5, 6, and 8 and the adaptor protein
As described by Glimcher and her colleagues, this adaptor protein
, or "master switch," regulates the growth of cells called osteoblasts that are responsible for bone formation.
In a second line of investigation, other, as yet unknown, proteins that might be involved in this process, like priming factors, and scaffold and adaptor proteins
will be explored.
This research, attempting to study roles of adaptor proteins
, TLR3 and MyD88, is important in providing a deeper understanding of TLR3's role in corneal inflammation, allowing for better designs in more effective anti-viral therapies.
Linker or adaptor proteins
act as scaffolds that organize the signaling proteins that cells need to proliferate and mature.