acyl carrier protein


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ac·yl car·ri·er pro·tein (ACP),

one of the proteins of the complex in cytoplasm that contains all of the enzymes required to convert acetyl-CoA (and, in certain cases, butyryl-CoA or propionyl-CoA) and malonyl-CoA to palmitic acid. This complex is tightly bound together in mammalian tissues and in yeast, but that from Escherichia coli is readily dissociated. The ACP thus isolated is a heat-stable protein with a molecular weight of about 10,000. It contains a free -SH that binds the acyl intermediates in the synthesis of fatty acids as thioesters. This -SH group is part of a 4'-phosphopantetheine, added to the apoprotein by ACP phosphodiesterase, which thus plays the same role that it does in coenzyme A. ACP is involved in every step of the fatty acid synthetic process.

Acyl Carrier Protein

A small 77-residue alpha helical bundle protein which is intimately involved in fatty acid biosynthesis, and binds various enzymes in pathways of primary and secondary metabolism. It was first isolated in Escherichia coli.

ac·yl car·ri·er pro·tein

(ACP) (as'il kar'ē-ĕr prō'tēn)
One of the proteins of the complex in cytoplasm that contains all the enzymes required to convert acetyl-CoA (and, in certain cases, butyryl-CoA or propionyl-CoA) and malonyl-CoA to palmitic acid. This complex is tightly bound together in mammalian tissues and in yeast, but that taken from Escherichia coli is readily dissociated. The ACP thus isolated is a heat-stable protein with a molecular weight of about 10,000. It contains a free -SH that binds the acyl intermediates in the synthesis of fatty acids as thioesters. This -SH group is part of a 4'-phosphopantetheine, added to the apoprotein by ACP phosphodiesterase, which thus plays the same role that it does in coenzyme A. ACP is involved in every step of the fatty acid synthetic process.

acyl

1. an organic radical derived from a fatty acid by removal of the hydroxyl group.
2. generic term for fatty acid groups.

acyl carrier protein
ACP; a carrier protein molecule which is part of the fatty acid synthesizing enzyme complex in non-mammalian systems and which carries acyl groups.
acyl CoA
thioester of coenzyme A and a fatty acid of unspecified, but usually more than 14 carbon length.
acyl CoA dehydrogenase deficiency
lack of the first enzyme of beta-oxidation, acyl CoA dehydrogenase, a flavoprotein which catalyzes the removal of two hydrogens from the acyl chain.