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acyl-CoA dehydrogenase
(redirected from Acyl CoA dehydrogenase)

   Also found in: Wikipedia 0.01 sec.
acyl-CoA dehydrogenase /ac·yl-CoA de·hy·dro·gen·ase/ (de-hi´dro-jen-ās) any of several enzymes that catalyze the oxidation of acyl coenzyme A thioesters as a step in the degradation of fatty acids. Individual enzymes are specific for certain ranges of acyl chain lengths: long-chain a.-CoA d. (LCAD), medium-chain a.-CoA d. (MCAD), and short-chain a.-CoA d. (SCAD).


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Medium Chain Acyl CoA Dehydrogenase Deficiency (MCADD) can be easily managed once diagnosed but often the first sign is when the sufferer is taken seriously ill.
Well-known mitochondrial diseases of children are Leigh's syndrome, cardiomyopathty, and medium-chain acyl CoA dehydrogenase (MCAD) deficiency Typical mitochondrial diseases of young adults include Leber's hereditary optic neuropathy and Kearns-Sayre syndrome.
Many disorders and syndromes were eliminated as the focus turned to something called short-chain acyl CoA dehydrogenase deficiency, a fatty acid oxidation disorder within the larger category of mitochondrial disorders.
 
 
 
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