acute phase protein

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acute phase protein

plasma proteins associated with inflammation including C-reactive protein (CRP), mannose-binding protein, serum amyloid P component, α1-antitrypsin, fibrinogen, ceruloplasmin, and complement components C9 and factor B, the concentrations of which increase in response to interleukins 1, 6, and 11.

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation
See also: protein
References in periodicals archive ?
Serum concentrations of low molecular weight proteins are primarily determined by GFR, and an ideal marker should have a constant production rate and not vary in concentration during an acute-phase reaction.
Lipton, patients treated with denosumab had an 8% incidence of a flu-like, acute-phase reaction during the first 3 days after the start of treatment, compared with a 33% rate in patients randomized to treatment with an intravenous bisphosphonate.
It has been suggested that the SELDI-TOF MS technology has a preference toward detection of high-abundance protein molecules, such as acute-phase reaction proteins.