Acute phase reactant

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Acute Phase Reactant

Any of a number of proteins that migrate in the alpha1 and alpha2 regions of a serum protein electrophoresis, which are elevated in acute inflammation. Acute phase reactants traditionally include alpha1-antitrypsin, alpha1 acid glycoprotein, amyloid A and P, anti-thrombin III, CRP, C1-esterase inhibitor, C3 complement, ceruloplasmin, fibrinogen, haptoglobin, orosomucoid, plasminogen, transferrin; reference ranges increase and the values themselves decrease with age. Acute phase reactants often have specific roles—e.g., acting as endogenous pyrogens or somnogens.


A chemical or substance taking part in a chemical reaction.

acute phase reactant

Acute phase protein.

limiting reactant

The substance with the lowest concentration in a chemical reaction. Its amount determines the amount of product made from that reaction.

Acute phase reactant

A substance in the blood that increases as a response to an acute conditions such as infection, injury, tissue destruction, some cancers, burns, surgery, or trauma.
References in periodicals archive ?
The acute phase reactants are elevated in all inflammatory disorders whether acute or chronic.
The combination of WBC count >10,000 can be taken as one of the reliable laboratory parameter of acute phase reactant.
Serum WBC, CRP, and procalcitonin levels are the most widely studied acute phase reactants in child and adult CAP cases (5).
Indicators of disease in RA could be a gene, a product of gene expression, cytokines, acute phase reactants, autoantibodies and tissue abnormalities, such as swollen and tender joints or degradation products of cartilage.
KEY WORDS: Acute brucellosis, Serum amyloid A, C-reactive protein, Erythrocyte sedimentation rate, Acute phase reactant.
In one study, the acute phase reactant serum amyloid A was found to be significantly elevated in participants with allergic rhinitis and asthma.
C-reactive protein: from acute phase reactant to cardiovascular disease risk factor.
This acute phase reactant has been studied over the last several years in a wide variety of atherosclerotic diseases (12,16-20).
24 The reasons for NGAL increase in AKI are acute tubular injury and NGAL secretion from neutrophils, macrophages, and other immune cells as an acute phase reactant.
AA amyloidosis is associated with increased hepatocyte production of the acute phase reactant serum amyloid A (SAA); in chronic inflammatory disorders, this process may be stimulated by the release of cytokines (perhaps interleukin-1) from activated macrophages1.

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