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transplant rejection
(redirected from Acute organ rejection)

   Also found in: Wikipedia 0.01 sec.
transplant
1. an organ or tissue taken from the body and grafted into another area of the same individual or another individual.
2. to transfer tissue from one part to another or from one individual to another.

ovum transplant
see ovum transplant.
transplant rejection

transplant rejection
Graft rejection, organ rejection, tissue rejection Immunology The constellation of host immune responses evoked when an allograft tissue is transplanted into a recipient; rejection phenomena may be minimized by optimal matching of MHC antigens and ABO blood groups and ameliorated with immunosuppressants–eg, cyclosporin, tacrolimus, rapamycin Exceptions of TR Corneal transplants, identical twins. See Graft-versus-host disease, HLA, MHC, Tissue typing.


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Biomarkers in Transplantation, a research initiative that will allow doctors to identify patients rejecting transplanted organs with a simple blood test, is making use of advanced genomic, proteomic, and computational tools to develop the test, which will diagnose rejection before acute organ rejection occurs, allowing doctors to intervene early and to personalize a patient's immunosuppressant therapy.
CellCept was first approved for use in combination therapy for the prevention of acute organ rejection in kidney transplantation in 1995 and has since been approved worldwide for prevention of organ rejection in adult kidney, heart and liver transplantation.
Reduced cyclosporine concentrations have been documented when orlistat and cyclosporine are taken together, and the FDA has received postmarketing reports of reduced cyclosporine concentrations and two cases of acute organ rejection in orlistat users.
 
 
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