ACVR2A

(redirected from Activin receptor type IIA)

ACVR2A

A gene on chromosome 2q22.3 that encodes activin receptor type IIA, a receptor that forms a complex with other type-I and two type-II  transmembrane serine/threonine kinase receptors for activin, a dimeric growth and differentiating factor belonging to the TGF-beta superfamily of structurally related signalling proteins. Type-I receptors are essential for signalling; type-II receptors are required for binding ligands and expression of type-I receptors. After activin binding, type-I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors, playing roles in cell differentiation, growth arrest and apoptosis.
References in periodicals archive ?
Sotatercept, a soluble receptor fusion protein comprised of extracellular domain of the human activin receptor type IIA (ActRIIA) fused to human immunoglobulin, is a biologic therapeutic.
ACE-011, A SOLUBLE ACTIVIN RECEPTOR TYPE IIA IGG-FC FUSION PROTEIN, INCREASES HEMOGLOBIN AND IMPROVES BONE LESIONS IN MULTIPLE MYELOMA PATIENTS RECEIVING MYELOSUPPRESSIVE CHEMOTHERAPY: PRELIMINARY ANALYSIS" (Oral Presentation); Hall F, December 7th, 5:30 PM
RAP-011, A SOLUBLE ACTIVIN RECEPTOR TYPE IIA MURINE IGG-FC FUSION PROTEIN, PREVENTS CHEMOTHERAPY INDUCED ANEMIA" (Oral Presentation); Rooms 220-222, December 6th, 5:30 PM
Innovative Approach Through Activin Receptor Type IIA May Lead to New Treatment Option for Patients with Chemotherapy-Induced Anemia --
ACE-011, a soluble form of the activin receptor type IIA (ActRIIA), is a biologic therapeutic that binds to and prevents signaling of several members of the TGF-beta protein super family, and has been shown to stimulate red blood cell production, promote bone formation, and inhibit tumor growth and metastasis.
ACE-011, a soluble form of the activin receptor type IIA (ActRIIA), is a biologic therapeutic agent that inhibits signaling through the ActRIIA receptor, a member of the Growth and Differentiation Factor (GDF) family of proteins.
The results from the oral presentation titled "ACE-011, A Soluble Activin Receptor Type IIA Fusion Protein, Increases BMD and Improves Microarchitecture in Cynomolgus Monkeys" were presented at The American Society for Bone and Mineral Research (ASBMR) 29th Annual Meeting held in Honolulu, Hawaii, USA, September 16 - 19, 2007.