An estradiol/norethindrone hormone replacement therapy combination for treating vasomotor symptoms and vulvovaginal atrophy of menopause.
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Group II: A fix dose estrogen-progestin combination (estradiol 1mg and norethisterone acetate 0,5mg/day; Activelle tb, Novo Nordisk, Istanbul, Turkey) n=60;
In order to avoid confounding effects of different gestagens, Activelle, a low-dose oral hormone preparation containing the same gestagen, was preferred.
Activelle is a continuous-combined HRT, which means that both estrogen and progestogen are continuously administered.