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Active Placebo

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Active Placebo
A placebo with side effects similar to those of a therapeutic agent—administered in the context of a therapeutic trial, which would otherwise allow a patient to identify whether he/she is receiving drug or placebo—e.g., dry mouth with chlorpromazine

active placebo
Statistics A placebo with side effects similar to those of a therapeutic agent which would otherwise allow a Pt to identify whether he is receiving drug or placebo–eg, dry mouth is associated with chlorpromazine. Cf Placebo.


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Reduction of HAM-D and BDI scores when the two actively treated groups are pooled together: non-dysthymic patients Active Placebo Total p-value Reduction in Hamilton score to < 7 Yes n = 28 n = 6 n = 34 0.
Ideally, there would also be an active placebo comparator in the study of a complementary treatment.
Researchers are also considering the use of so-called active placebos, compounds that lack the effective ingredient in a drug but may cause some of its side effects.
 
 
 
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