fos

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Related to Activator protein 1: Activator Protein 2

FOS

A gene on chromosome 14q24.3 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.

fos

(fas)
A family of cancer-causing genes, first identified in viruses, that function within cells as transcription factors. Members of this family can transform normal cells (e.g., fibroblasts) into cancer cells (e.g., osteosarcomas, chondrosarcomas). See: oncogene; transformation

Etiology

The name is derived from “FBJ osteosarcoma virus, ” in which these oncogenes were first identified.

References in periodicals archive ?
Expression of FRA-1 was also studied, because FRA-1 belongs to the activator protein 1 family of transcription factors and members of this family are known to interact with NF-[kappa]B.
This is in agreement with the previously published finding of cross talk between p65 and Fos-Jun heterodimers of activator protein 1.
Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.
Inhibition of activator protein 1 activity and neoplastic transformation by aspirin.
Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.