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activated protein C resistance |
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activated protein C resistance APC resistance Hematology A condition caused by an inherited defect in the anticoagulant response to APC and clinically characterized by ↑ venous thrombosis; it is responsible for 20-50% of DVT
Pathogenesis Protein C, a key regulator of coagulation, circulates in an inactivated form and is activated by the binding of thrombin to thrombomodulin receptors on vascular endothelial cells; once activated, protein C lyses coagulation factors
Va and VIIIa; APCR may be due to a selective defect in factor V coagulant function How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| ? Mentioned in | ? References in periodicals archive | |
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The frequency of activated protein C resistance has been reported
to occur at least tenfold more frequently than deficiencies of protein
C, protein S and antithrombin III combined. |
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