Acquired Mutation


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Related to Acquired Mutation: somatic mutation, conditional mutant

Acquired Mutation

Genetics A post-meiotic alteration in a DNA sequence, which can be passed to the mutated cell’s progeny and linked to the development of cancer.
Molecular biology A non-heritable genetic change in a somatic cell; a somatic mutation.
References in periodicals archive ?
Heteroplasmy arises with certain types of inherited mtDNA mutations as well as in cases of acquired mutations.
They specifically found that bed bugs in New York City have acquired mutations in their nerve cells, which blunt the neurotoxic effect of the pyrethroid toxins used against them.
STDs - sexually transmitted diseases), acquired mutations in cancer that affect the response to drugs (e.
Doctors have identified acquired mutations of the gene GATA-1 in nearly all newborns with Down Syndrome (DS) who develop a transient myeloproliferative disorder (termed TMD), an abnormal hematologic condition seen shortly after birth or in the neonatal period that is characterized by leukocytosis, an abnormal increase in white blood cell count, and thrombocytopenia, a low platelet count in the blood.
Eighty-five percent of colorectal cancers result from chromosomal instability, with acquired mutations progressively accumulating in the adenomatous polyposis coli (APC) and p53 tumor suppressor genes, and in the k-ras oncogene.
The team then used electronic medical records to follow the patients' subsequent medical histories, finding that the subjects with these acquired mutations had a 13-times elevated risk of blood cancer.
We began with stem cells taken from cord-blood, which have fewer acquired mutations and little, if any, epigenetic memory, which cells accumulate as time goes on," Elias Zambidis from Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center said.
Recent research indicates that human leukemias develop through a step-wise process, resulting from multiple acquired mutations in cellular clones leading to clinical disease.
103,107-110) Less frequent causes of acquired resistance to EGFR TKIs include acquired mutations of phosphatidylinositol-3-kinase (PI3K), transformation to small cell lung cancer, epithelial to mesenchymal transition, and KRAS mutations.
8% of children with T-cell leukemia (T-ALL) harbor acquired mutations in the ribosome, the cellular protein translation factory.

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