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Related to Aciphex: Prevacid, Rabeprazole, Nexium, Zantac, Pariet

rabeprazole sodium

AcipHex, Novo-Rabeprazole (CA), Pariet (UK), PMS-Rabeprazole (CA), Ran-Rabeprazole (CA)

Pharmacologic class: Proton pump inhibitor

Therapeutic class: Gastric antisecretory agent

Pregnancy risk category B


Reduces gastric acid secretion and increases gastric mucus and bicarbonate production, creating a protective coating on gastric mucosa


Tablets (delayed-release): 20 mg

Indications and dosages

Erosive or ulcerative gastroesophageal reflux disease (GERD)

Adults: 20 mg P.O. daily for 4 to 8 weeks. If healing doesn't occur within 8 weeks, another 8 weeks of therapy may be considered. Maintenance dosage is 20 mg P.O. daily.


Adults: 20 mg P.O. daily for 4 weeks. If symptoms don't resolve after 4 weeks, another course of therapy may be considered.

Short-term treatment of symptomatic GERD

Adolescents ages 12 and older: 20 mg P.O. daily for up to 8 weeks

Hypersecretory conditions, including Zollinger-Ellison syndrome

Adults: Initially, 60 mg P.O. daily; adjust dosage as needed up to 100 mg P.O. daily as a single dose or 60 mg P.O. b.i.d. Maximum daily dosage is 120 mg.

Duodenal ulcer

Adults: 20 mg P.O. daily for up to 4 weeks

Helicobacter pylori eradication

Adults: 20 mg P.O. b.i.d. for 7 days (given with amoxicillin and clarithromycin)

Off-label uses

• Dyspepsia
• Benign gastric ulcer


• Hypersensitivity to drug, its components, or benzimidazoles


Use cautiously in:
• severe hepatic impairment
• concurrent use of atazanavir (not recommended)
• pregnant patients
• breastfeeding patients (not recommended)
• children (safety not established).


• Don't crush or split tablets.
• Give without regard to food.

Adverse reactions

CNS: headache

Metabolic: hypomagnesemia

Musculoskeletal: fractures of hip, wrist, spine (with long-term daily use)


Drug-drug.Atazanavir: substantially decreased atazanavir plasma concentration and reduced therapeutic effect Combined administration of rabeprazole, amoxicillin, and clarithromycin: increased rabeprazole and 14-hydroxyclarithromycin plasma concentrations

Gastric pH-dependent drugs (such as digoxin, ketoconazole): increased or decreased absorption

Methotrexate: possibly elevated and prolonged methotrexate serum level

Warfarin: increased risk of bleeding

Drug-diagnostic tests.Magnesium: decreased level

Patient monitoring

• Stay alert for symptomatic response, but know that a positive response doesn't rule out gastric cancer.
• Monitor magnesium level before starting therapy and periodically thereafter in patients expected to be on prolonged therapy or who take proton pump inhibitors with drugs such as digoxin or drugs that may cause hypomagnesemia (such as diuretics).

Patient teaching

• Tell patient he may take with or without food. Instruct him not to crush, chew, or split tablets.
• Caution female patient not to breastfeed during therapy.
• As appropriate, review all significant adverse reactions and interactions, especially those related to the drugs mentioned above.


A trademark for the drug rabeprazole sodium.


An oral proton pump inhibitor used to manage erosive or ulcerated gastrooesophageal reflux disease (GORD/GERD), gastric and duodenal ulcers, and Zollinger-Ellison syndrome.
Adverse effects Diarrhoea, nausea, vomiting, constipation, rash, headaches.


Rabeprazole, see there.
References in periodicals archive ?
On March 26, 2013, the US Food and Drug Administration approved ACIPHEX Sprinkle Delayed-Release Capsules 5mg and 10mg for the treatment of Gastroesophageal Reflux Disease (GERD) in children 1 to 11 years of age for up to 12 weeks.
The gastrointestinal disorders therapeutics market is set to experience strong generic competition during the forecast period, as several major branded drugs used in to treat gastrointestinal disorders are set to expire during 2011-2015, including Nexium (esomeprazole magnesium), Aciphex (rabeprazole sodium), Tysabri (natalizumab) and Humira (adalimumab).
Food and Drug Administration today approved the first generic versions of Aciphex (rabeprazole sodium) delayed-release tablets, used to treat gastroesophageal reflux disease (GERD) in adults and adolescents (ages 12 and up).
Because clopidogrel can irritate the stomach in some patients, many doctors also prescribe a PPI such as Prilosec, Nexium, Aciphex, Prevacid or Protonix.
s Aciphex, a drug to stop excess production of stomach acid, in 20 milligram delayed-release tablets.
He takes 32 Viokase pills daily to supplement his diet, plus AcipHex, Imodium, and vitamins.
PPIs include omeprazole, lansoprazole, pantoprazole, Nexium (esomeprazole) and Aciphex (rabeprazole); and histamine blockers such as ranitidine, nizatidine, famotidine and cimetidine.
The drug company Janssen-Eisai, which makes the antacid Aciphex, funded part of the study.
Eisai attributed the increase mainly to strong sales of Aricept, a drug for the treatment of Alzheimer's disease, and Pariet, a drug for peptic ulcers sold as Aciphex in the United States, as well as to a pension-related one-time gain of 3.
Therapies used to treat GERD include: Aciphex (rabeprazole sodium), Dexilant (dexlansoprazole), Nexium (esomeprazole), Prevacid (lansoprazole), Prilosec (omeprazole), Protonix (pantoprazole sodium), Zegerid (omeprazole/sodium bicarbonate), Axid (nizatidine) and Pepcid (famotidine).
61 billion yen on strong sales of its anti-ulcer drug Aciphex, which jumped 18.