nucleus accumbens

(redirected from Accumbens)
Also found in: Wikipedia.

nu·cle·us ac·cum·'bens

[TA]
the region of fusion between the head of the caudate nucleus and the putamen, covered on its inferior aspect by the olfactory tubercle. Its former name nucleus accumbens septi ("a nucleus leaning against the septum") refers to a medial, hook-shaped expansion of this anteroventral region of the striatum, which curves under the floor of the frontal horn of the lateral ventricle and ascends for some distance into the ventral half of the septal region. Composed of a pars lateralis [TA] (lateral part [TA] or core region [TAalt]) and a pars medialis [TA] (medial part [TA] or shell region [TAalt]).

nucleus accumbens

A limbic nucleus that sits at the ventral head of the striatum, contiguous with the caudate and putamen and adjacent to the olfactory tubercle. The nucleus accumbens is part of the ventral striatum nuclei. Synapses in the nucleus accumbens use dopamine as their neurotransmitter. Increasing the activity of these synapses (i.e., increasing the level of dopamine in the nucleus) leads to a rewarding or pleasurable sensation. This is thought to partly explain the addictive effect of those drugs, such as cocaine and amphetamine, that increase the level of dopamine in the nucleus accumbens.
See also: nucleus
References in periodicals archive ?
Anticipation of increasing monetary reward selectively recruits nucleus accumbens.
The next time you see an exceptional parent nibbling on an OREO cookie whether it's before the start of an IEP meeting, a clinic appointment, an appeals review, a conference or an interview appreciate that their nucleus accumbens is probably lighting up like a Christmas tree .
In all of these disorders, a region called the nucleus accumbens, which provides a communication link between the emotional and reasoning centers of the brain, is particularly important because of its role in eliciting and modulating behavior.
Comment: The presence of a subnormal concentration of glutamate in the nucleus accumbens region of the brain may increase compulsive or addictive behaviors and heighten cravings.
Dopamine reuptake inhibition observed after sertraline administration in in vivo experiments seems to be parallel to the dopamine increase in nucleus accumbens and striatum of rats observed after sertraline intake.
One projects to a reward center, the nucleus accumbens, and the other to a nearby fear center, the centromedial amygdala, the output station of the emotion hub.
I found that hevin is induced by chronic social stress in the nucleus accumbens (NAc), a key brain reward region, only in resilient individuals.
In a study on rodents, investigators from the National Institute on Drug Abuse used tracers to confirm that the reward pathways started with glutamate cells in the dorsal raphe nucleus, which connect to dopamine cells in the ventral tegmental area, which eventually lead to the nucleus accumbens, a brain structure important to reward, pleasure, and motivation.
Studies on the brains of these motivation-sapped mice revealed a difference in a group of nerve cells in the nucleus accumbens, an area involved in the pursuit of rewards.
Risk-taking teens also had increased activity between regions of the prefrontal cortex and the nucleus accumbens, a centre for reward sensitivity that is often implicated in addiction research.
In addition, limonene reversed the increase in dopamine levels in the nucleus accumbens of rats given methamphetamine.
Interestingly, the impulsive models showed increased expression of a transcription factor called Delta-FosB in the nucleus accumbens, an area of the brain involved in reward evaluation and impulsive behavior, indicating a potential biological component to this behavior.