nucleus accumbens

(redirected from Accumbens)

nu·cle·us ac·cum·'bens

[TA]
the region of fusion between the head of the caudate nucleus and the putamen, covered on its inferior aspect by the olfactory tubercle. Its former name nucleus accumbens septi ("a nucleus leaning against the septum") refers to a medial, hook-shaped expansion of this anteroventral region of the striatum, which curves under the floor of the frontal horn of the lateral ventricle and ascends for some distance into the ventral half of the septal region. Composed of a pars lateralis [TA] (lateral part [TA] or core region [TAalt]) and a pars medialis [TA] (medial part [TA] or shell region [TAalt]).

nucleus accumbens

A limbic nucleus that sits at the ventral head of the striatum, contiguous with the caudate and putamen and adjacent to the olfactory tubercle. The nucleus accumbens is part of the ventral striatum nuclei. Synapses in the nucleus accumbens use dopamine as their neurotransmitter. Increasing the activity of these synapses (i.e., increasing the level of dopamine in the nucleus) leads to a rewarding or pleasurable sensation. This is thought to partly explain the addictive effect of those drugs, such as cocaine and amphetamine, that increase the level of dopamine in the nucleus accumbens.
See also: nucleus
References in periodicals archive ?
For this purpose, we evaluated locomotor activity across the course of exposure, whereas monoamine levels in striatum, prefrontal cortex, nucleus accumbens, and hypothalamus and stereologic cell counts of TH-positive (T[H.
Thanes, injected a virus carrying the D2 receptor gene into the nucleus accumbens (the pleasure center of the brain) of rats.
3 shows the response as a carbon-fiber microelectrode is lowered through the nucleus accumbens in 150-[micro]m increments, while dopamine fibers in the medial forebrain bundle were electrically stimulated.
En el presente trabajo se revisan algunas de las evidencias derivadas de estudios clinicos y experimentales que apoyan la idea de que el sistema mesolimbico y el nucleo accumbens parecen estar implicados en las acciones neurofarmacologicas de las terapias antidepresivas y, por tanto, en algunos aspectos de la sintomatologia de la depresion.
The drive sub-system resides in the nucleus accumbens.
The researchers conducted their tests on mice, using "chemo-genetic and optical techniques to remotely control the activities of nucleus accumbens neurons and the behaviors they mediate.
Mice fed with the poor diet during adolescence had reduced levels of n-3 PUFA in the medial prefrontal cortex and the nucleus accumbens in adulthood compared to control mice.
Subjects with hoarding disorder proved to have significantly greater serotonin transporter binding than healthy controls in the bilateral amygdala, nucleus accumbens, putamen, and right caudate nucleus.
There does not appear to be a significant therapeutic difference between stimulation of the thalamus or globus pallidus although stimulation of the anterior limb of the internal capsule and nucleus accumbens seems to be less effective (25%–50%) for treating TS.
The alterations were found in the nucleus accumbens, a brain region involved in reward-related learning.
Within this circuitry, the dopaminergic neurons in the ventral tegmental area (VTA) are projected to the nucleus accumbens (NAc, a part of the ventral striatum), prefrontal cortex (PFC), amygdala, and hippocampus.
No single SNPs or "polygenic risk scores" from the 108 study were significantly associated with size of the amygdala, hippocampus, thalamus, nucleus accumbens, or any other subcortical region.