Accelerated Atherosclerosis

Accelerated Atherosclerosis

Atherosclerosis which occurs in a person with certain risk factors—e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease—at an earlier age than would occur in another person without those risk factors.
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1) Chronic inflammation is the most important reason for accelerated atherosclerosis development in RA.
LAL Deficiency is a chronic disease in which genetic mutations result in decreased activity of the LAL enzyme; this leads to marked accumulation of lipids in vital organs, blood vessels, and other tissues, resulting in progressive and multi-systemic organ damage including fibrosis, cirrhosis, liver failure, accelerated atherosclerosis, cardiovascular disease, and other devastating consequences.
LAL Deficiency causes progressive and multisystemic organ damage including hepatic cirrhosis and accelerated atherosclerosis that can lead to sudden and unpredictable clinical complications.
Accelerated atherosclerosis in systemic lupus erythematosus has been attributed to the disease or to glucocorticoid therapy.
People with severe inflammatory conditions (like rheumatoid arthritis and lupus) suffer accelerated atherosclerosis.
Clinical trials in children and adults have shown that starins do not prevent accelerated atherosclerosis in SLE, so they are not helpful.
Kawasaki disease, a serious childhood illness that causes inflammation of blood vessels throughout the body, has been linked with early-onset and accelerated atherosclerosis, a leading cause of heart disease in adults.
But very high levels have been linked to risk factors for cardiovascular disease, such as the metabolic syndrome - symptoms of which include obesity and high blood pressure - and accelerated atherosclerosis - where fatty deposits build up on the walls of the arteries.
The effects of cortisol are intended to help the body recover from stress and regain a status of homeostasis, however chronically elevated cortisol levels have been associated with cardiovascular risk factors, such as the metabolic syndrome and accelerated atherosclerosis.
However, most of the evidence linking HIV with accelerated atherosclerosis has emerged in the post-HAART era.
27) In light of the cumulative data that lupus patients have an interferon signature that correlates with disease activity and severity, it may be that interferon alpha is the primary cytokine mediator of accelerated atherosclerosis in SLE patients.

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