Acanthamoeba


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Acanthamoeba

 [ah-kan″thah-me´bah]
a genus of free-living ameboid protozoa found usually in fresh water or moist soil. Certain species, such as A. castella´ni, A. poly´phaga, A. astronyx´is, and A. culbert´soni, may occur as opportunistic human pathogens, causing an acute fatal or chronic infection of the eye, brain, liver, kidney, lung, pancreas, and skin in patients with underlying disease or in immunocompromised patients.

Acanthamoeba

(ă-kan'thă-mē'bă),
A genus of free-living ameba (family Acanthamoebidae, order Amoebida) found in and characterized by the presence of acanthopodia. Human infection includes invasion of skin or colonization following injury, corneal invasion and colonization, and possibly lung or genitourinary tract colonization; a few cases of brain or central nervous system invasion have occurred, but not solely by the olfactory epithelium route of entry as with the more virulent infections caused by Naegleria fowleri. Species responsible are chiefly Acanthamoeba culbertsoni, but cases have been reported involving Acanthamoeba castellanii, Acanthamoeba polyphaga, and Acanthamoeba astronyxis. Most cases have been chronic rather than fulminating and rapidly fatal as with N. fowleri infection.
[G. akantha, thorn, spine, + Mod. L. amoeba, fr. G. amoibē, change]

Acanthamoeba

/Acan·tha·moe·ba/ (ah-kan″thah-me´bah) a genus of free-living ameboid protozoa (order Amoebida) found usually in fresh water or moist soil. Certain species, such as A. astronyxis, A. castellanii, A. culbertsoni, A. hatchetti, A. polyphaga, and A. rhisodes, may occur as human pathogens.

Acanthamoeba

[əkan′thəmē′bə]
a genus of free-living ameboid protozoa typically found in moist soil and water. The organisms may enter the body through a break in the skin or even though the nasal mucosa, olfactory nerve, and mucous membranes of the eye. It may cause severe infections, such as keratitis (eye infection that can lead to blindness especially with contact lens wearers), and systemic infections of the lung, genitourinary system, brain, and central nervous system. Disseminated cutaneous lesions caused by this organism are seen particularly in patients with AIDS. Although an infection may be fatal, cases are more commonly chronic and can persist for months.

Acanthamoeba

A genus of free-living pathogenic amoebae, which are ubiquitous in the environment, the cycle of which consists of 2 stages: a trophozoite (which is 14–40 µm in diameter) and a cyst (which has a double-layered wall with a diameter of 12–16 µm).

Sources
Tap water, dust, soil, sewage, air-conditioning units.
 
Diseases caused by:
Amoebic keratitis, acanthamoeba granulomatous encephalitis.

Acanthamoeba

A genus of free-living pathogenic amoebas Sources tap water, dust, soil, sewage, air conditioning units. See Acanthamebiasis. Cf Leptomyxid, Naegleria.

Acanthamoeba

small amebae, found in soil and water; they have been found in tissue cultures and in sporadic cases of pneumonia, general systemic infection and can produce meningoencephalitis after experimental administration. Possibly associated with granulomatous encephalitis in greyhounds. Includes A. castellani, A. culbertsoni.
References in periodicals archive ?
In addition, the company said Impavido has received orphan drug designation in treating Primary Amebic Meningoencephalitis (PAM), the brain infection caused by the water-born amoeba Naegleria fowleri and Acanthamoeba Keratitis, and is the first Rx product launched in the US.
This is exactly why we supported the No Water sticker campaign by Irenie Ekkeshis, who has campaigned relentlessly after contracting Acanthamoeba keratitis.
17) found CXL ineffective both in vitro and in vivo against Acanthamoeba trophozoites.
Legionella pneumophila, nontuberculous mycobacteria, Acanthamoeba, Naegleria fowleri, Pseudomonas aeruginosa, to name a few) in drinking water distribution and plumbing systems has continued to grow in significance as a public health concern.
These is the case of Enterobacter aerogenes, Aeromonas hydrophila and Legionella pneumophila, which have been observed to survive within vacuoles of Acanthamoeba castellanii, inhibiting the fusion of the phagolysosome [27].
Free-living amebae belonging to the genus Acanthamoeba are found worldwide in air, dust, and water and are relatively resistant to normal levels of chlorine in tap water.
In 2014, Moorfields Eye Hospital in London launched its Healthy Habits campaign to educate people about the risks after consultants saw an increase in sight-threatening infections, such as acanthamoeba keratitis, which is caused by a parasite found in soil, fresh water and seawater.
After the patient was admitted, a repeat corneal smear was performed, and the scrapings were sent for bacterial (aerobes/anaerobes), fungal, and Acanthamoeba cultures and tested for antibiotic sensitivity.
Wearing them increases the risk of contracting an infection from acanthamoeba - parasites that live in water," says Dr Blakeney.
Acanthamoeba keratitis is a potentially blinding infection of the cornea that primarily occurs in individuals who wear contact lenses.
In the first comprehensive review of Acanthamoeba research, Khan reviews everything that has been published about the organism and has arranged the information to allow readers to understand and access it easily.