Absolute Risk Reduction


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Absolute Risk Reduction

Epidemiology A measure of the treatment effect, comparing the probability—or mean of a type of outcome in the control group—with that of a treatment group.
EBM The absolute arithmetic difference in the risk—i.e., the rate of an adverse event or outcome—between a study (treated/experimental) population and a control population.
References in periodicals archive ?
The difference in absolute risk reduction between Michigan and its neighbors is not attributable to a greater rate of facility closure over time in Michigan.
Absolute risk reduction of complicated gastrointinal events: perforation, ulceration, clinically significant bleeding, obstruction Study, N, Median duration Intervention % on ASA of follow-up (months) CLASS 9 Celecoxib N = 8 029 400 mg bd 22% VIGOR 9 Rofecoxib N = 8 076 50 mg od 0% TARGET 12 Lumiracoxib N = 18 325 400 mg od 24% MEDAL Not reported Etoricoxib 60 programme *** (study longer or 90 mg od N = 34 701 > 36 months 33% (40% on PPI) Study, N, Comparison Risk difference Numbers % on ASA of annualised needed to risk (%) treat (NNT) CLASS Combined NSAIDs 0.
The largest absolute risk reduction for perforation was found for women considered to be of menstruating, childbearing age.
To provide perspective, the following discussion focuses on the absolute risk reduction and the numbers needed to treat associated with two preventive health measures that have been widely researched and endorsed: (1) preventing coronary artery disease by treating hypercholesterolemia and (2) preventing fractures by treating osteoporosis.
1 percent, and 56 percent with an absolute risk reduction of 1.
7%), which correlates to an absolute risk reduction of 6.
Second, a lot of clinicians have a tendency to enjoy numbers less, and so working with likelihood ratios, or numbers needed to treat, or absolute risk reduction sometimes seems a bit intimidating.
On an individual basis, a 55-year-old woman with the most nonmodifiable risk factors could see the biggest benefit, an absolute risk reduction of 4.
That being said, the size of the absolute risk reduction depends upon prognosis.
3% absolute risk reduction, one life would be saved for every seven patients treated with selenium.