The new study also showed that neurons from HspB1-deficient mice were more sensitive to the toxic ravages of Abeta
We knew that Type 2 diabetes could increase the risk for Alzheimer's disease, but we were not sure how that risk was caused or whether that diabetes risk would impact Abeta
levels in the brain.
After one year, however, these mice have Abeta
plaques, as well as a decrease in spine density due to the effect of Abeta
, which is known to be neurotoxic.
About CogRx's Small Molecule Soluble Abeta
Receptor Antagonist Program CogRx has discovered small molecule drug candidates that can dramatically reduce toxic Abeta
oligomer binding to receptor proteins on the brain cells at synapses by over 90%.
Investigators collected preliminary evidence of treatment efficacy including cognitive and global measures and secondary outcomes including activities of daily living, behavioral disturbances, pharmacokinetic parameters and a number of Alzheimer's disease biomarkers including Abeta
It is possible the result may point to PBT2 targeting soluble species of Abeta
including toxic oligomers rather than plaques.
In a previous study, Holtzman had shown that synaptic activity triggers Abeta
release, suggesting that the sleep-deprived mice in the current study churned out more Abeta
because their brains were revved up longer than usual.
ACC-001 (active Abeta
immunotherapeutic conjugate) is currently in Phase 1 clinical trials.
Caffeine, at levels comparable to 5 cups of coffee daily, reduces levels of the proteins that go into manufacture of Abeta
, and lowers levels of Abeta
itself in blood and brain tissue.
The Phase 1 trials for ACC-001 (active Abeta
immunotherapeutic conjugate) are progressing as planned.
19), (44) It slows cell death following exposure to the dangerous "Alzheimer's protein" called Abeta
(amyloid beta), and other oxidant stressors.
11 - New animal models validate pyroGlu Abeta
as target in Alzheimer's disease H.