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AZT

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
AZT zidovudine.
AZT (z-t)
n.
Azidothymidine; a nucleoside analog antiviral drug that inhibits the replication of retroviruses such as HIV by interfering with the enzyme reverse transcriptase.

AZT,
trademark for a human immunodeficiency virus inhibitor (Zidovudine). Also called Retrovir.

zidovudine [zi-do´vu-dēn]
a nucleoside analogue to thymidine, used as an antiretroviral agent in treatment of patients with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS); administered orally or intravenously. It was the first agent approved for such use.

AZT,
n the abbreviation for azidothymidine. See also azidothymidine.

AZT
azidothymidine.

AZT
3'-azido-3'-deoxythimidine, zidovudine, Retrovir AIDS A nucleoside analogue, used with other anti-HIV agents to manage AIDS and HIV infection Adverse effects Long-term AZT use is associated with muscle loss, nausea, anemia, myelosuppression, oral ulcers, BM damage, headache. See AIDS, HAART.


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Briefly, some of the liposomes carrying the active substances (lithium and AZT in this particular case) are phagocytized by the macrophages both in the blood circulation and in the HIV sanctuary organs with subsequent lysis and sustained release of the above components.
While AZT and its chemical cousins could delay HIV progression, none of them alone or in 2-drug combinations could durably control HIV, let alone reverse its associated immune suppression and threat of opportunistic diseases.
The picture is different for the four-drug combination AZT + 3TC + abacavir + tenofovir, which is showing good results even though it contains one of the problematic combinations within it.
 
 
 
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