AUG codon

AUG codon

codon for methionine; usually, but not always the first AUG sequence encountered as the mRNA is read 5′→3′ is the translational start signal; the methionine encoded is cleaved from the polypeptide.
References in periodicals archive ?
Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivo.
Base-pairing interactions between the Shine-Dalgarno sequence and the anti-Shine-Dalgarno sequence momentarily tether the mRNA to the face of the 30S ribosomal subunit and increase the likelihood that an appropriately spaced AUG codon will be utilized during translational initiation (reviewe d in 3).
In estimating our results, we had in mind the first initiation codon, which is thought to have more favorable flanking sequences for initiation of protein synthesis, although use of leaky scanning mechanism could be the reason of initiation at the second AUG codon (21).