ATP4B

(redirected from ATPase, H+/K+ exchanging, beta polypeptide)

ATP4B

A gene on chromosome 13q34 that belongs to a family of P-type cation-transporting ATPases; it is composed of heterodimers consisting of a high molecular weight catalytic alpha subunit and a smaller, heavily glycosylated beta subunit, which catalyse the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane and are responsible for gastric acid secretion. Overactivity of H+, K+-ATPases causes gastric inflammation, and are the pharmacologic target for managing peptic ulcers, dyspepsia and gastro-oesophageal reflux disease (GERD/GORD).
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