ATP1A3


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ATP1A3

A gene on chromosome 19q13.31 that encodes an enzyme belonging to the family of P-type cation transport ATPases and the subfamily of Na+/K+ -ATPases, the latter of which are responsible for establishing and maintaining electrochemical gradients of Na and K ions across the plasma membrane; they are required for osmoregulation in sodium-coupled transport of various organic and inorganic molecules, and for electrical excitability of nerve and muscle.
References in periodicals archive ?
Researchers managed to breed the defect out of epileptic mice by balancing "good" and "bad" genes - the researchers found genes without the defective version of ATP1A3 cancelled out genes with it during breeding.
The research suggested that the mice shared a defective ATP1A3 gene, which is responsible for pumping sodium and potassium ions across the cell membrane.