ATP1A2

ATP1A2

A gene on chromosome 1q21-q23 that encodes an alpha 2 (catalytic) subunit of the family of P-type cation transport ATPases and subfamily of Na+/K+ -ATPases. These Na+/K+ -ATPases are heterodimers composed of a large alpha subunit and a smaller beta subunit, and are responsible for establishing and maintaining the electrochemical gradients of Na and K ions across plasma membranes. These electrochemical gradients are required for osmoregulation, sodium-coupled transport of various organic and inorganic molecules and electrical excitability of nerve and muscle.

Molecular pathology
ATP1A2 mutations are linked to familial basilar or hemiplegic migraines, and alternating hemiplegia of childhood.
References in periodicals archive ?
More recently, mutations in ATP1A2 on chromosome 1g23 that encode the [[alpha].