ATP1A1

ATP1A1

A gene on chromosome 1p21 that encodes an alpha 1 (catalytic) subunit of the family of P-type cation transport ATPases and subfamily of Na+/K+ -ATPases. These Na+/K+ -ATPases are heterodimers composed of a large alpha subunit and a smaller beta subunit, and are responsible for establishing and maintaining the electrochemical gradients of Na and K ions across plasma membranes. These electrochemical gradients are required for osmoregulation, sodium-coupled transport of various organic and inorganic molecules and electrical excitability of nerve and muscle.
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Cattle Multiple breeds Linear regression PLA2G5, ATP1A1, (1,500) DAG1 Belgian Blue (26) Case-control ATPA2A1 (ASSHOM/ASSIST) Belgian Blue (31) Case-control SLC6A5 (ASSHOM/ASSIST) Italian Chianina Case-control ABCA12 (12) (ASSHOM/ASSIST) Holstein cows Case-control (Plink) EDN2, SOD1, (245) PARP1 etc Black/Red Angus Case-control (Plink) MC1R (76) Holstein bulls Linear regression/ DGAT1, ABCG2, (5,360) Bayesian methods Integrin jj2 etc.
Porcine chromosome SSC 4p13 contains a synteny group, with F13B, ATP1B1, GBA, ATP1A1, IVL, and two microsatellites S0001, S0067 (Andersson et al.