P2RY1

(redirected from ATP receptor)

P2RY1

A gene on chromosome 3q25.2 that encodes a G protein-coupled receptor that acts as a receptor for extracellular ATP and ADP. In platelets, P2RY1 binding to ADP leads to mobilisation of intracellular calcium ions by activating phospholipase C, a change in platelet shape and platelet aggregation.
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Using a reporter gene assay, we conducted initial characterization of the ATP receptor through analog specificity studies using P2X receptor agonists and antagonists with differing receptor subtype selectivity.
1] cells and lead us to conduct preliminary characterization of the ATP receptor on [GH.
This study highlights the potential importance of ATP as a mediator of airway diseases and prompts further research in this area, particularly with the recent development of specific ATP receptor blockers," said Professor Barnes.
He continued research to reveal the functions of many ATP receptors expressed in microglia on the synaptic transmission resulting in strong pain and then received a Medal with Purple Ribbon from His Majesty the Japanese Emperor in 2014 for these findings.
Activated spinal microglia enhance their expression of the ATP receptors subtype P2X4; and the presence of ATP leads to neuropathic pain.
Specific topics include regulated releases of nucleotides and UDP sugars from astrocytoma cells, ectonucleotidases in the nervous system, ATP receptors of microglia involved in pain, and promoting neurotrophic effects by GPCR ligands.