ACLY

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ACLY

A gene on chromosome 17q21.2 that encodes ATP citrate lyase, the main enzyme responsible for synthesising cytosolic acetyl-CoA, which catalyses the formation of acetyl-CoA and oxaloacetate from citrate and CoA with hydrolysis of ATP to ADP and phosphate. Acetyl-CoA serves several important biosynthetic pathways, including lipogenesis and
cholesterogenesis; in nervous tissue, it is involved in the biosynthesis of acetylcholine.
References in periodicals archive ?
HCAP(TM), after permeation through the skin, is digested into HCA by the action of an enzyme inside cells, inhibiting the activity of ATP citrate lyase.
Citrate, converted to Acetyl CoA by ATP citrate lyase (ACL) in the cytoplasm and nucleus, is required for histone acetylation by HATs.
Reactivity and inhibitor potential of hydroxycitrate isomers with citrate synthase, citrate lyase, and ATP citrate lyase.
Both tissues had very low abundance for ATP citrate lyase.