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ATLANTISAlteplase ThromboLysis for Acute Noninterventional Therapy in ischaemic Stroke. A trial testing the efficacy of rt-PA (alteplase) in patients with acute ischaemic stroke when administered between three and five hours after the onset of symptoms. Alteplase had been previously approved for use within three hours of symptoms onset.
Excellent neurologic recovery at day 90.
No rt-PA benefit on 90-day end point in patients treated between three and five hours, but risk of symptomatic ICH increased with rt-PA; rt-PA for stroke should be limited to three hours post-symptom onset.