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ATIMEQuinapril (Accupril) Titration Interval Management Evaluation. A trial that asked if slowing the dose escalation of quinapril, a long-acting ACE inhibitor, would improve hypertension control rates with fewer adverse effects.
Conclusion Yes. 10% more patients achieved the target blood pressure (140/90) with slow-titration; 12% of the slow group had adverse events vs 21% of fast patients.