ATF4


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ATF4

A gene on chromosome 22q13.1 that encodes a transcription activator protein belonging to a family of DNA-binding proteins, which includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins.
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2004; Rutkowski and Kaufman 2004), we determined the expression of ATF4 and the phosphorylation of eukaryotic translation initiation factor 2 on serine 51 of its [alpha] subunit (eIF2[alpha]), an upstream regulator of ATF4 expression (Harding et al.
Accumulation of ATF4 and phosphoeIF2[alpha] by Cd[Cl.
The levels of ATF4 and phospho-eIF2[alpha] proteins were elevated in cells exposed to Cd[Cl.
On the other hand, another transcriptional factor, ATF4 (also known as CREB2), can bind to an ATF/CRE-like site upstream of the ER stress elements in the mammalian Grp78 promoter (Luo et al.
In contrast to most proteins, ATF4 circumvents this translation block because it has upstream open reading frames in its 5' untranslated region that are bypassed only when eIF2[alpha] is phosphorylated (Harding et al.