ATF2


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ATF2

A gene on chromosome 2q32 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds to the cAMP-responsive element (CRE) and stimulates CRE-dependent transcription.
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It turns out that ATF2 blocks MITF function in the early stages of melanocyte development.
To determine exactly how ATF2 keeps the damper on MITF, the researchers then drilled down to melanocytes and melanoma cells in a dish.
In about half the cell lines tested, they noted that ATF2's control over MITF is indirect - ATF2 actually controls a protein, called SOX10, which is in turn necessary for MITF expression.