ASS1

ASS1

A gene on chromosome 9q34.1 that encodes an enzyme which catalyses the penultimate step of the arginine biosynthetic pathway.
 
Molecular pathology
ASS1 mutations cause citrullinemia type 1.
References in periodicals archive ?
ASS1 plays an important role in the synthesis of the amino acid arginine, which is required for cell growth and function.
PRO, ASS1 45/10/1/39 (Information of Katherine Firth).
PRO, ASS1 45/9/1/119 (Information of Philippa Bedill).
We now have a number of Phase 1 and Phase 2 clinical trials underway with ADI-PEG 20 in cancers that are ASS1 deficient, not only as monotherapy, but also combined with one or two other agents.
ASS1 deficiency in certain cancer cells requires these cells to obtain arginine from the circulation in order to survive.
1435) found that 6 of 12 NSCLC cell lines were ASS1 deficient.
They found that ASS1 loss was linked to several pro-tumorigenic functions, including increased cell invasiveness and migration.
of Chimei Hospital in Taiwan, will present data about ASS1 deficiency in sarcoma and its potential use as an indicator for cancer prognosis and treatment.
Arginine deprivation by ADI-PEG 20 induces autophagy and cell death in cell lines deficient in ASS1.
During this period, certain melanoma cells can turn on the ASS1 gene and hence become resistant to ADI-PEG 20.
Lack of expression of ASS1 causes the tumor cells to rely on externally supplied arginine for survival and thus become susceptible to arginine-degrading enzymes such as ADI-PEG 20.
A lack of ASS1 protein was identified in three of seven leukemic cell lines and in all nine samples acquired from AML patients.