BACE1

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BACE1

B-site amyloid precursor protein (APP) cleaving enzyme. An aspartic-acid protease encoded by BACE1 on chromosome 11q23.2.-q23.3, which is linked to the pathogenesis of Alzheimer's disease and the formation of myelin sheaths in peripheral nerve cells. BACE1 is a transmembrane aspartic protease (beta-secretase) found in the Golgi apparatus, trans-Golgi network, secretory vesicles, and endosomes. It cleaves amyloid precursor protein (APP) in the brain into amyloid beta peptide, a major component of the amyloid plaques of Alzheimer's disease (AD), the deposition of which is the central pathology in AD, for which BACE1 is potential therapeutic target.
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A new inlet works is also required as part of the scope of works, which would replace part of the existing ASP2 inlet works and reduce flow to the existing ASP1 / storm inlet works.
The conclusive isolation of the ASP2 gene through genome analysis, and the subsequent application of cell biology and biochemistry, takes the scientific community one step closer to finding a targeted treatment for Alzheimer's disease," said Mark Gurney, Ph.
The recent discovery of the ASP2 gene and the improved isolation techniques using genome analysis enable scientists to focus on developing compounds that block the activity of the ASP2 protease and the development of the Alzheimer's disease-causing amyloid plaques.