MAP3K5

(redirected from ASK1)
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MAP3K5

A gene on chromosome 6q22.33 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K5 activates the P38 and JNK MAPK pathways in response to various signals, including calcium and GPCR signalling and endoplasmic
reticulum stress. It is highly expressed in the heart and pancreas.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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normal cells), a protein called p21 is expressed and-in the presence of rapamycin-binds to ASK1 and inactivates it.
The strategy of using rapamycin to block mTOR and activate ASK1 could be thwarted by another survival factor, called IGF-I.
IGF-I prevents rapamycin from activating ASK1, and therefore shuts down the pathway that leads to apoptosis," Houghton said.
The authors also showed that ASK1 was an upstream activator of JNK1 (79).