ARPC2

ARPC2

A gene on chromosome 2q36.1 that encodes p34, one of the seven subunits of the Arp2/3 protein complex, which is thought to control actin polymerisation in cells; its exact role is unknown.
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PA inhibited the expressions of ARPC2 and CTNND1 that are associated with the formation of actin cytoskeleton, focal adhesion and cellular protrusions.
The primary antibodies against CDK 4, cyclin D1, p21/Cip, mTOR, phospho-mTOR (Ser2448), phospho-4EBP1 (Ser65), S6 Ribosomal Protein, phospho-S6 Ribosomal Protein (Ser235/236) were purchased from Cell Signaling Technology (Beverly, MA); [beta]-actin and 4E-BP1 were obtained from Sigma; ARPC2 was purchased from Abeam (Burlingame, CA); GRB-2 was purchased from BD Biosciences (Bedford, MA).
The protein expressions of CDK 4 (cellular growth and proliferation), ARPC2 (cellular assembly and organization) and GRB-2 (cell-to-cell signaling) detected from western blot analyses corroborated to their respective iTRAQ ratios (Fig.
ARPC2 as the structural core subunit of Arp2/3 complex is critical for its integrity and thus the actin nucleation function (Gournier et al.