ARNT


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ARNT

A gene on chromosome 1q21 that encodes aryl hydrocarbon receptor, which is involved in inducing several enzymes that participate in xenobiotic metabolism—e.g., of dioxin and polycyclic aromatic hydrocarbons—resulting in translocation of the ligand-binding subunit to the nucleus.

Molecular pathology
A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia.
References in periodicals archive ?
We've shown that there's likely to be decreased ARNT in the liver of people with Type 2 diabetes compared to people without Type 2 diabetes," said Gunton.
097, and 2939 amol of mRNA in 260 ng of total RNA, respectively, for AHR, ARNT, CYP1B1, IL-1[beta], and [beta]-ACT.
The ARNT (aryl hydrocarbon receptor nuclear translocator) gene is a member of a family of transcription factors essential for normal embryonic development and also is involved in response to conditions of hypoxia and certain environmental toxins, such as dioxin.