ARF1


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ARF1

A gene on chromosome 1q42 that encodes a protein of the ADP-ribosylation factor gene family, which encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and are involved in vesicular trafficking as phospholipase D activators. ARF1 localises to the Golgi apparatus and has a central role in intra-Golgi transport.
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Also, when ARF1 activity was chemically blocked, breast cancer cell migration and growth was reduced.
On the other hand, when ARF1 was overproduced in these cells, their movement was enhanced.
Taken together our findings reveal an unsuspected role for ARF1 and indicate that this small protein may be a potential therapeutic target for the treatment of invasive breast cancers," said Dr.