ARF protein


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ARF protein

Any of a family of small G proteins involved in vesicle trafficking, so named for their ability to support ADP-ribosylation of the trimeric G protein, Gs, which is an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase involved in protein trafficking. ARFs act by vesicle budding from Golgi cisternae and other membrane compartments, and mediate GTP-dependent stimulation of phospholipase D.
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The 22 ARF proteins encoded by 22 ARF genes in Arabidopsis genome each contain a conserved DNA binding domain near their N terminus and most also have a dimerization domain near their C terminus that can interact with a corresponding domain in Aux/IAA proteins (Ulmasov et al.
Auxin probably activates ARF proteins by regulating turnover of ARF-interacting proteins called Aux/IAAs (Dharmasiri & Estelle, 2004).
We need to understand how the large families of AUX/IAA and ARF proteins regulate downstream gene expression.