APUD cells


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Related to APUD cells: carcinoid syndrome, Paneth Cells, Enteroendocrine cells, duodenal stenosis, Galactose metabolism, DNES cells

APUD cells

 (amine precursor uptake and decarboxylation)
a group of apparently unrelated cells that secrete most of the body's hormones, with the exception of steroids. Included are both specialized neurons and other endocrine cells that synthesize structurally related polypeptides and biogenic amines. The name comes from the fact that polypeptide production is linked to the uptake of a precursor amino acid and its decarboxylation in the cell to produce an amine. Examples of the peptide hormones are insulin, corticotropin, glucagon, and antidiuretic hormone. Examples of the amine hormones are dopamine, norepinephrine, serotonin, and histamine.

apud

Designation for a group of cells in different organs secreting polypeptide hormones or neurotransmitters. Cells in this group have certain biochemical characteristics in common, the first letters of which form the acronym that designates the group; they contain amines, such as catecholamine and 5-hydroxytryptamine, take up precursors of these amines in vivo, and contain amino-acid decarboxylase.
Synonym(s): DNES cells
[amine precursor uptake, and decarboxylation]

APUD

, APUD cells (ap'ŭd, selz)
Designation for cells in various organs secreting polypeptide hormones. Cells in this group have certain biochemical characteristics in common: they contain amines, such as catecholamine and 5-hydroxytryptamine; take up precursors of these amines in vivo; and contain amino acid decarboxylase.
[amine precursor uptake, decarboxylase]

APUD cells

(amine precursor uptake and decarboxylation) a group of cells of common embryonic origin that secrete most of the body's hormones, with the exception of steroids. APUD cells comprise both specialized neurons and other endocrine cells. These cells synthesize structurally related polypeptides and biogenic amines. The acronym APUD derives from the fact that polypeptide production is linked to the uptake of a precursor amino acid and its decarboxylation in the cell to produce an amine. Examples of the peptide hormones are insulin, ACTH, glucagon and antidiuretic hormone. Examples of the amine hormones are dopamine, norepinephrine, serotonin and histamine.

APUD tumor
see apudoma.