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APP |
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APP amyloid precursor protein.
amyloid precursor protein (APP), a large transmembrane glycoprotein expressed on the cell surface and of uncertain function; it may be cleaved on the cell surface to a soluble form. Alternatively, cleavage may follow endocytosis and in some cases then yields 40 to 43 abnormal amino acid peptides, which aggregate to form Ab amyloid, associated with Alzheimer's disease. APP Amyloid β protein precursor A membrane-spanning glycoprotein of unknown function, which is expressed in many mammalian tissues, the gene for which maps to chromosome 21. See Alzheimer's disease, β-amyloid. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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