APP

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APP

amyloid precursor protein.

APP

abbr.
amyloid precursor protein

amyloid precursor protein (APP)

a large transmembrane glycoprotein expressed on the cell surface and of uncertain function; it may be cleaved on the cell surface to a soluble form. Alternatively, cleavage may follow endocytosis and in some cases then yields 40 to 43 abnormal amino acid peptides, which aggregate to form Ab amyloid, associated with Alzheimer's disease.

APP

A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

APP

Amyloid β protein precursor A membrane-spanning glycoprotein of unknown function, which is expressed in many mammalian tissues, the gene for which maps to chromosome 21. See Alzheimer's disease, β-amyloid.