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A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).


Academy of Pharmaceutical Physicians and Investigators.
References in periodicals archive ?
Tufail said that APPI is an investment oriented agreement to harmonize investment related laws in all 10 countries.
The three-part APPI certification course will be available in select markets in 2011.
Physiotherapists Elisa and Glenn Withers established the APPI in 1999 in response to the demand for rehabilitation-based Pilates teacher training.
After repeated complaints by traders and term clients, the APPI panel on April 1, 1997, introduced twice-weekly assessments to make them more responsive to changes in the spot market.
Because of a slow response by the APPI panel, spot market premia over this index have been eliminated.
For the last six years, APPI has used a local area network (LAN) and The Cat's Pajamas software to handle book fulfillment.
APPI uses the contracted warehouse and shipping service of Professional Mail Distribution Services (PMDS), Jessup, Maryland.
With Mocana's Embedded SSL Client APPI can now guarantee a secure, quality product for its customers that will effectively protect data during every transaction that takes place on POS devices transacting over a network.
Syagen will supply the PhotoMate[R] APPI source to the majority of the liquid chromatography/mass spectrometry (LC/MS) instrument manufacturers and Applied Biosystems/MDS SCIEX will supply the Photospray[R] APPI source to customers of its LC/MS product line.
APPI markets and distributes its line of products including Lo-Chol(tm) worldwide through various sales distribution channels.
Syagen's PhotoMate line of APPI sources are sold to leading OEM customers such as Agilent, Thermo Electron, Waters, and Shimadzu.
APPI is an important complement to electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) by expanding the range and classes of compounds that can be analyzed, including nonpolar molecules that are not easily ionized by ESI or APCI, and by exhibiting less ion suppression than these other sources.