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apolipoprotein E |
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apolipoprotein E, a protein component of lipoprotein complexes found in very-low-density lipoprotein (VLDL), high-density lipoprotein, chylomicrons, and chylomicron remnants. It facilitates hepatic uptake of chylomicron and VLDL remnants and is elevated in patients with type III hyperlipoproteinemia. One form of apolipoprotein E has been linked to Alzheimer's disease. apolipoprotein E A 34-kD cholesterol-binding glycoprotein, which comprises 15% of VLDL; apoE maps to chromosome 19, is secreted by macrophages that mediate the uptake of lipoproteins–VLDL, HDL, LDL and cholesterol esters into cells via
distinct binding domains for each receptor; apo-E has a central role in the metabolism of TG-rich lipoproteins, and mediates the uptake of chylomicrons and VLDL by the liver How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The ApoE gene is the blueprint for a protein that helps deliver cholesterol, a critical building block of the membranes of newly forming cells. In contrast, only 13 percent of the 531 people carrying another version of the APOE gene showed such problems during the study, says cardiologist Angelo Scuteri of NIA. The ApoE gene has three variants (or alleles), E2, E3, and E4. |
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