APOE


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APOE

A gene on chromosome 19q13.2 that encodes apolipoprotein E, the main apoprotein of chylomicrons, which binds to a specific receptor on liver cells and peripheral cells. ApoE mediates binding, internalisation and catabolism of lipoprotein particles and serves as a ligand for the LDL (apo B/E) receptor.

Molecular pathology
APOE mutations cause hyperlipoproteinaemia type III (familial dysbetalipoproteinaemia), which is characterised by increased plasma cholesterol and triglycerides due to impaired chylomicron and VLDL remnant clearance.

APOE

ε4 Molecular neurology The type 4 allele of the apolipoprotein E gene locus located on chromosome 19, which may↑ the risk of late-onset Alzheimer's disease, and has been associated with ↓ cerebral parietal metabolism; possession of an APOE ε4 allele is a strong predictor for cognitive decline. See Alzheimer's disease.

apolipoprotein

(ap?o-li?po-pro'te(-i)n) [ apo- + lipoprotein],

Apo

Any of the proteins imbedded in the outer shell of lipoproteins. The apolipoproteins are designated ApoAI, ApoAII, ApoAIV; ApoB48 and B100; ApoCI, ApoCII, ApoCIII; and ApoE. Except for ApoAII and ApoAIV, they metabolize and transport lipoproteins. The functions of ApoAII and ApoAIV are not fully understood. All are synthesized in the liver.

apolipoprotein E

Abbreviation: ApoE
A protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer disease, possibly because it protects neurons less effectively than other ApoE alleles.

apolipoprotein J

Clusterin. See: lipoprotein

apolipoprotein E

Abbreviation: ApoE
A protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer disease, possibly because it protects neurons less effectively than other ApoE alleles.
See also: apolipoprotein
References in periodicals archive ?
Moreover, the same LDL-C measurements could be used to evaluate the outcome of therapy directly, which is not currently possible with the APOE or any other genetic variation.
Typically, greensheets are used only in sporadic instances, such as when a surge of shipments creates a backlog at one of the APOEs.
Presence of the APOE [epsilon]4 allele has been documented to increase vulnerability to negative neurocognitive and functional outcomes in TBI.
Following demonstration that the APOE polymorphisms affect both inflammatory response and survival following caecal ligation and puncture, we determined the ability of a peptide derived from the receptor binding region of apoE, COG1410, to produce an anti-inflammatory effect and reduce mortality in wildtype C57BL6/J mice.
It was assumed that each shipper appearing on the list with frustrated cargo during the research time period shipped at least one piece of frustrated HAZMAT through an APOE annually.
In diagnosing AD, APOE testing is not a common practice.
Deploying medical capability piecemeal could necessitate the use of a large number of APOEs.
Kristine Yaffee, the primary author of this study, published in Neurology (2000;54:1948-53), doesn't suggest that women go out and have their APOE genotype tested just yet.
Previous research derived from the same study shows that possession of even one copy of the APOE e4 gene accelerates age related memory decline beginning in the mid to late 50's and for that subset that has two copies of the gene the effect is more pronounced.
As expected, APOE e4 carriers showed greater cognitive decline over time than noncarriers; however, a subset of APOE e4 carriers showed high retention of cognitive status, compared with demographically similar noncarriers.
Both homozygous and heterozygous APOE epsilon-4 carriers had more test-specific distress than did carriers of other APOE alleles, said coauthor Leo B.