APOC1

APOC1

A gene on chromosome 19q13.2 that encodes a member of the apolipoprotein C1 family expressed primarily in the liver and activated when monocytes differentiate into macrophages. APOC1 is thought to modulate the interaction of APOE with beta-migrating VLDL and inhibit beta-VLDL binding to the LDL-receptor-related protein. It binds free fatty acids and reduces their intracellular esterification.
References in periodicals archive ?
Statistical significance was confirmed with a Satterthwaite t-test for APOC1, CXCL11, and CXCL9.
We identified 7 novel biomarkers as statistically significant in discriminating protein concentrations in blood from men with advanced prostate cancer compared to controls: APOC1, ASPN, COMP, CXCL11, CXCL9, F5, and PCSK6.
In a sub-set of the cohort selected for neutral risk at the APOE locus, they detected a significant association in SNPs located within TOMM40 and APOC1, two genes that flank APOE.