APOB


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APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
References in periodicals archive ?
An additional critical finding in this study was an 8% reduction in apoB from baseline in the supplemented group--a significant reduction since apoB is the core protein in the deadly LDL cholesterol particle.
1) ApoB is seen in VLDL, IDL, and LDL, and its increased levels are associated with CAD.
2]; Lp(a), lipoprotein a; ApoA1, apolipoprotein A-I; ApoB, apolipoprotein B-100; apo(a), apolipoprotein(a); WHS, Women's Health Study; BNP, B-type natriuretic peptide; NT-proBNP, N-terminal prohormone of BNP; CHS, Cardiovascular Health Study; DHS, Dallas Heart Study; SNP, single-nucleotide polymorphism; CAC, coronary artery calcification.
24) Several other considerations may make non-HDL-C a superior measure to LDL-p or apoB for initial assessment and on-treatment/management decisions in the majority of circumstances, including the well-established targets for non-HDL-C, its ease of calculation, its well-documented intervention effects, and the fact that it can be obtained without additional cost or data collection beyond the standard lipid profile.
Despite some study limitations, we were able to use the major 2009 guideline criteria to classify individuals in the different risk, treatment, and control categories, including ApoB, hs-CRP, family history, and the Framingham and Reynolds computed CVD risk levels.
In conclusion, our results show that ADH in North-West Morocco is not mainly due to neither LDLR nor APOB gene mutations.
ApoB is a protein found on all atherogenic (bad) lipoproteins present in blood circulation, and elevated apoB values represent increased risk for heart disease.
The apoB transcript was highly expressed in the liver of laying Taiwan Country chickens (Figure 2).
In an average of 21 years' follow-up, the APOB [epsilon]4 carriers were 2.
Researchers also found that the HDL3 subfraction was protective from CHD events overall, independent of apoA1 and apoB levels.
The goal of the current article was to compare apoB to NMR LDL-P for prediction of CVD risk and other diseases and conditions.
Our results demonstrate a robust long-term knock-down of ApoB by AAV-delivered miApoB in murine liver, thus providing an excellent candidate for the development of RNAi-based gene therapy," stated Dr Harald Petry, Head of Research at AMT.