APOA2


Also found in: Acronyms.

APOA2

A gene on chromosome 1q21-q23 that encodes apolipoprotein A2, a protein component of high-density lipoprotein (HDL), which is present in plasma as a monomer, homodimer or heterodimer with apolipoprotein D.

Molecular pathology
APOA2 mutations cause apolipoprotein A2 deficiency or hypercholesterolaemia.
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Despite the scarcity of previous data supporting a role of APOA2 in regulating food intake, copious experimental evidence demonstrates a pivotal role of another apolipoprotein, APOA4, as a satiety signal (20, 21, 39, 40).
As these effects were consistently found in both men and women, we suggest a new role for APOA2 in regulating food intake.
9] Nonstandard abbreviations: APOA2, apolipoprotein A-II; CVD, cardiovascular disease; GOLDN, Genetics of Lipid Lowering Drugs and Diet Network; BMI, body mass index; DHQ, diet history questionnaire; PUFA, polyunsaturated fat; SATFAT, saturated fat; IDL, intermediate-density lipoprotein; OR, odds ratio; MUFA, monounsaturated fat.
10] Human genes: APOA2, apolipoprotein A-II; HTR2A, 5-hydroxytryptamine (serotonin) receptor 2A.