butorphanol tartrate

(redirected from APO-Butorphanol)

butorphanol tartrate

APO-Butorphanol (CA), PMS-Butorphanol (CA), Stadol

Pharmacologic class: Opioid agonist-antagonist

Therapeutic class: Opioid analgesic

Controlled substance schedule IV Pregnancy risk category C

Action

Alters perception of and emotional response to pain by binding with opioid receptors in brain, causing CNS depression. Also exerts antagonistic activity at opioid receptors, which reduces risk of toxicity, drug dependence, and respiratory depression.

Availability

Injection: 1 mg/ml, 2 mg/ml

Nasal spray: 10 mg/ml

Indications and dosages

Moderate to severe pain

Adults: 1 to 4 mg I.M. q 3 to 4 hours as needed, not to exceed 4 mg/dose. Or 0.5 to 2 mg I.V. q 3 to 4 hours as needed. With nasal spray, 1 mg (one spray in one nostril) q 3 to 4 hours, repeated in 60 to 90 minutes if needed.

Labor pains

Adults: 1 to 2 mg I.V. or I.M., repeated after 4 hours as needed

Preoperative anesthesia

Adults: 2 mg I.M. 60 to 90 minutes before surgery

Balanced anesthesia

Adults: 2 mg I.V. shortly before anesthesia induction, or 0.5 to 1 mg I.V. in increments during anesthesia

Dosage adjustment

• Renal or hepatic impairment
• Elderly patients

Off-label uses

• Headache
• Symptomatic relief of ureteral colic

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• head injury, ventricular dysfunction, coronary insufficiency, respiratory disease, renal or hepatic dysfunction
• history of drug abuse.

Administration

• Make sure solution is clear and free of particulates before giving.
• When using nasal spray, insert tip of the sprayer about ¼″ into nostril, point tip backwards, and administer one spray.
• Be aware that I.V. route is preferred for severe pain.

Know that drug may cause infant respiratory distress in neonate of pregnant patient, especially if given within 2 hours of delivery.

butorphanol tartrate

[byo̅o̅tôr′fənôl]
an agonist/antagonist opioid of the phenanthrene family.
indications It is administered parentally for surgical premedication, as an analgesic component of balanced anesthesia, for prompt relief of moderate to severe pain associated with surgical procedures, and as a nasal spray for the relief of migraine pain.
contraindications Butorphanol tartrate is not given to patients known to be sensitive to phenanthrenes or to persons dependent on opioids because it may provoke withdrawal symptoms.
adverse effects Toxicity may result from the use of butorphanol with other opioids.

butorphanol tartrate

a synthetic opioid with both agonist and antiagonist activities. It is used as an analgesic and antitussive.